Walter S, Klepzig H, Schmidts H L, Kaltenbach M
Z Kardiol. 1984 Jun;73(6):388-92.
In this study changes in weight and thickness of atheromatous vessel wall segments in relation to a varying duration (2-60 sec.) of a constant pressure application (5 kg/cm2) were investigated. Vessel wall segments were taken shortly postmortem from human femoral and external iliacal arteries. According to the type of atherosclerotic changes the samples were divided into 2 types (lipoidosis/sclerosis) before the experiments. As standard served non-atheromatous segments. During pressure application all specimens showed rapid decrease in weight and thickness within the first 40 seconds. After 50 seconds no further change could be seen. Atheromata predominantly containing lipids and few collagen fibres showed higher decrease in weight and thickness than those predominantly containing collagen and the control group. A positive correlation was shown between decrease in weight and thickness of the specimens. Is is concluded that squeezing out tissue fluid by pressure application may lead to a decrease in thickness of the atheromata; the enlargement of the luminal diameter achieved by balloon catheters may be attributed to this mechanism.
在本研究中，研究了在恒定压力（5kg/cm²）施加不同持续时间（2 - 60秒）的情况下，动脉粥样硬化血管壁段的重量和厚度变化。血管壁段在人体死亡后不久从股动脉和髂外动脉获取。根据动脉粥样硬化变化的类型，在实验前将样本分为2种类型（类脂沉积症/硬化症）。以非动脉粥样硬化段作为标准对照。在施加压力期间，所有标本在最初40秒内重量和厚度均迅速下降。50秒后未见进一步变化。主要含有脂质和少量胶原纤维的动脉粥样硬化斑块，其重量和厚度的下降幅度高于主要含有胶原的斑块以及对照组。标本的重量和厚度下降之间呈正相关。得出的结论是，通过施加压力挤出组织液可能导致动脉粥样硬化斑块厚度减小；球囊导管实现的管腔直径增大可能归因于这一机制。
