Webster R C, Kattner M D, Smith R C
Arch Otolaryngol. 1984 Oct;110(10):652-6. doi: 10.1001/archotol.1984.00800360024005.
We treated 87 patients with injectable collagen during a period of 2 1/2 years. Intradermal augmentations were found to be particularly valuable in frown grooves, the groove between the cheek and the lips and chin, the groove beneath the malar prominence, and the groove just lateral to the labial commissure, and for enhancement of malar pads or prominences. Less successfully treated were fine lines, postrhinoplastic depressions, and punched-out, depressed scars. The augmentations are less permanent, more painful, and more costly than those provided by subdermal injections of silicone, but injectable collagen is available generally for these purposes and injectable silicone is not. Problems of allergy also are drawbacks to the use of injectable collagen. Even with its disadvantages, however, injectable collagen is presently valuable in total care of aging faces and certain scarring.
在两年半的时间里，我们对87例患者进行了可注射胶原蛋白治疗。皮内填充在眉间纹、脸颊与嘴唇及下巴之间的沟纹、颧骨突出下方的沟纹、口角外侧的沟纹以及用于提升颧脂肪垫或颧骨突出方面特别有价值。对于细纹、隆鼻术后凹陷以及点状凹陷性瘢痕，治疗效果欠佳。与皮下注射硅酮相比，胶原蛋白填充维持时间较短、疼痛更明显且费用更高，但一般可获得可注射胶原蛋白用于这些目的，而可注射硅酮则不然。过敏问题也是使用可注射胶原蛋白的缺点。然而，尽管有这些缺点，可注射胶原蛋白目前在全面护理衰老面部和某些瘢痕方面仍有价值。
