Orbach-Arbouys S, Andrade-Mena C E, Berardet M, Mathe G
Behring Inst Mitt. 1984 May(74):258-61.
After the intraperitoneal injection of aclacinomycin into mice, a variety of immune responses are increased. The responsible mechanism is the elimination of suppressor cells since aclacinomycin inhibits the expression of tolerance to SRBC in mice and diminishes the capacity of spleen cells from SRBC-tolerant mice to inhibit the response of normal animals upon adoptive transfer, either when injected to the donor tolerant mice before the cell transfer or when in vitro incubated with the tolerant cells for 1 hour: both treatments had eliminated suppressor cells from the tolerant spleen cell population.
给小鼠腹腔注射阿克拉霉素后，多种免疫反应增强。其作用机制是消除抑制性细胞，因为阿克拉霉素可抑制小鼠对绵羊红细胞（SRBC）耐受性的表达，并降低来自SRBC耐受小鼠的脾细胞在过继转移时抑制正常动物反应的能力，无论是在细胞转移前注射到供体耐受小鼠体内，还是在体外与耐受细胞孵育1小时：这两种处理均已从耐受脾细胞群体中消除了抑制性细胞。
