Andrade-Mena C E, Orbach-Arbouys S, Mathé G
Immunopharmacology. 1985 Aug;10(1):19-25. doi: 10.1016/0162-3109(85)90055-4.
Aclacinomycin-A, a cytotoxic antibiotic, is capable of inhibiting the development and expression of suppressor cell activity for the contact sensitivity reaction to picryl chloride elicited by two intravenous injections of 3.5 mg picryl sulfonic acid when given as a single dose of 4 mg/kg 2 or 4 days before the first or 1 or 3 days after the second injection of picryl sulfonic acid. This inhibition may occur because aclacinomycin-A inhibits the development and expression of both suppressor T-cells and their precursors. In addition, it is shown that aclacinomycin-A diminishes the capacity of spleen T-cells from picryl sulfonic acid-injected mice to inhibit upon adoptive transfer the contact sensitivity reaction to picryl chloride of normal and presensitized animals.
阿克拉霉素A是一种细胞毒性抗生素，当在第一次注射3.5毫克苦味酸磺酸前2天或4天或第二次注射苦味酸磺酸后1天或3天给予4毫克/千克的单剂量时，它能够抑制由两次静脉注射苦味酸磺酸引发的对氯化苦基的接触敏感性反应中抑制细胞活性的发展和表达。这种抑制可能是因为阿克拉霉素A抑制了抑制性T细胞及其前体的发展和表达。此外，研究表明，阿克拉霉素A降低了来自注射苦味酸磺酸的小鼠的脾脏T细胞在过继转移时抑制正常动物和预致敏动物对氯化苦基的接触敏感性反应的能力。
