盐酸米安色林对人体去甲肾上腺素和5-羟色胺外周摄取机制的影响。
Effect of mianserin hydrochloride on peripheral uptake mechanisms for noradrenaline and 5-hydroxytryptamine in man.
作者信息
Coppen A, Ghose K, Swade C, Wood K
出版信息
Br J Clin Pharmacol. 1978;5 Suppl 1(Suppl 1):13S-17S.
Abstract
- Mianserin seems to have little effect on peripheral noradrenaline (NA) re-uptake mechanisms as shown by its lack of effects on the tyramine dose and NA dose/pressor response. 2. Mianserin has no effect on the hypotensive action of bethanidine. 3. Mianserin in vivo has a significant action on platlet transport (Vmax) of 5-hydroxytryptamine (5-HT), which changes toward normal values in depressive patients on the drug. This action is not observed in vitro. 4. It is possible that a metabolite of mianserin is responsible for this effect, and that this may be of therapeutic importance.
摘要
- 米安色林似乎对外周去甲肾上腺素（NA）再摄取机制几乎没有影响，这表现为它对酪胺剂量以及NA剂量/升压反应均无作用。2. 米安色林对苄胍的降压作用没有影响。3. 米安色林在体内对5-羟色胺（5-HT）的血小板转运（最大速度）有显著作用，服用该药物的抑郁症患者的这一转运向正常值变化。这种作用在体外未观察到。4. 米安色林的一种代谢产物可能是造成这种效应的原因，并且这可能具有治疗意义。
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Effect of mianserin hydrochloride on peripheral uptake mechanisms for noradrenaline and 5-hydroxytryptamine in man.盐酸米安色林对人体去甲肾上腺素和5-羟色胺外周摄取机制的影响。
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本文引用的文献
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Uptake and release of 14 C-5-hydroxytryptamine by platelets in affective illness.情感性疾病中血小板对14C-5-羟色胺的摄取与释放
J Neurol Neurosurg Psychiatry. 1971 Jun;34(3):224-5. doi: 10.1136/jnnp.34.3.224.
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Interactions between sympathomimetic amines and antidepressant agents in man.拟交感神经胺与抗抑郁药在人体中的相互作用。
Br Med J. 1973 Feb 10;1(5849):311-5. doi: 10.1136/bmj.1.5849.311.
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Platelet 5-HT uptake and release stopped rapidly by formaldehyde.
Nature. 1975 May 29;255(5507):407-8. doi: 10.1038/255407a0.
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Mianserin hydrochloride: a novel antidepressant.盐酸米安色林：一种新型抗抑郁药。
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Psychopharmacology (Berl). 1977 Aug 31;54(1):57-60. doi: 10.1007/BF00426542.
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