García-Mina J M, Grande F
Rev Esp Fisiol. 1984 Jun;40(2):177-81.
The antilipolytic activity of a series of N aryl-nicotinamides and of alpha picolinic acid, has been tested in vitro. Lipolysis was stimulated by epinephrine (20 micrograms/ml of incubation medium) using rat's epididymal adipose tissue slices. Only N(2-carboxy methyl phenyl) nicotinamide showed antilipolytic effect comparable to that of nicotinic acid at similar concentrations (2 X 10(-5) M). Picolinic acid (10(-4) M) showed no antilipolytic effect. These results, together with those of the literature, are discussed in regard to the relations between structure and antilipolytic activity.
已在体外测试了一系列N-芳基烟酰胺和α-吡啶甲酸的抗脂解活性。使用大鼠附睾脂肪组织切片，通过肾上腺素（20微克/毫升孵育培养基）刺激脂解。在相似浓度（2×10⁻⁵M）下，只有N-(2-羧甲基苯基)烟酰胺显示出与烟酸相当的抗脂解作用。吡啶甲酸（10⁻⁴M）未显示抗脂解作用。结合文献中的结果，讨论了结构与抗脂解活性之间的关系。
