Gorbunov M A, Sumarokov A A, Iaroshevskaia I Iu, Ikoev V N, Kudriakova R A
Zh Mikrobiol Epidemiol Immunobiol. 1984 Aug(8):101-4.
The article presents the results of a strictly controlled epidemiological experiment on the comparative evaluation of the effectiveness of two methols used for the immunoglobulin prophylaxis of hepatitis A; the simultaneous injection of immunoglobulin to all persons at risk at the beginning of the seasonal rise of morbidity and the injection of the preparation to all persons having contacts with hepatitis A patients in the foci of this infection as such foci appear. These results indicate that in the presence of a sufficiently high morbidity rate the injection of immunoglobulin at the beginning of the seasonal rise of morbidity proved to be most effective. Such use of immunoglobulin made it possible to decrease hepatitis A morbidity 2.1 times in comparison with the control groups and 1.5 times in comparison with the groups receiving the preparation in the foci of infection as such foci appeared.
本文介绍了一项严格控制的流行病学实验结果，该实验旨在比较两种用于甲型肝炎免疫球蛋白预防的方法的有效性；一种是在发病率季节性上升开始时对所有高危人群同时注射免疫球蛋白，另一种是在甲型肝炎感染疫源地出现时，对所有与甲型肝炎患者有接触的人注射该制剂。这些结果表明，在发病率足够高的情况下，在发病率季节性上升开始时注射免疫球蛋白被证明是最有效的。与对照组相比，这种使用免疫球蛋白的方法使甲型肝炎发病率降低了2.1倍，与在感染疫源地出现时接受该制剂注射的组相比降低了1.5倍。
