[Comparative evaluation of the effectiveness of 2 methods of immunoglobulin prophylaxis of hepatitis A in areas with high morbidity in this infection].

The article presents the results of a strictly controlled epidemiological experiment on the comparative evaluation of the effectiveness of two methols used for the immunoglobulin prophylaxis of hepatitis A; the simultaneous injection of immunoglobulin to all persons at risk at the beginning of the seasonal rise of morbidity and the injection of the preparation to all persons having contacts with hepatitis A patients in the foci of this infection as such foci appear. These results indicate that in the presence of a sufficiently high morbidity rate the injection of immunoglobulin at the beginning of the seasonal rise of morbidity proved to be most effective. Such use of immunoglobulin made it possible to decrease hepatitis A morbidity 2.1 times in comparison with the control groups and 1.5 times in comparison with the groups receiving the preparation in the foci of infection as such foci appeared.