Gutiérrez-Rodríguez O
Arthritis Rheum. 1984 Oct;27(10):1118-21. doi: 10.1002/art.1780271006.
In an open study, oral administration of thalidomide to 7 female patients with classic or definite rheumatoid arthritis, in doses ranging from 6.9 to 15 mg/kg/day, led to clinical improvement within several weeks. In 4 women, remission lasted long after discontinuation of the drug. All patients showed normalization or marked reduction of the erythrocyte sedimentation rate, and several showed a significant decrease in rheumatoid factor titer. Adverse side effects included drowsiness, constipation, and edema of the lower limbs, which disappeared after discontinuation of the drug.
在一项开放性研究中，对7名患有典型或确诊类风湿性关节炎的女性患者口服沙利度胺，剂量为6.9至15毫克/千克/天，数周内临床症状得到改善。4名女性患者在停药后缓解持续了很长时间。所有患者的红细胞沉降率均恢复正常或显著降低，几名患者的类风湿因子滴度也显著下降。不良反应包括嗜睡、便秘和下肢水肿，停药后这些症状消失。
