柳氮磺胺吡啶在类风湿关节炎中的毒性。类风湿因子和皮质类固醇可能的保护作用。

Toxicity of sulphasalazine in rheumatoid arthritis. Possible protective effect of rheumatoid factors and corticosteroids.

作者信息

Gran J T, Myklebust G

机构信息

Department of Rheumatology, Central Hospital of Aust Agder, Arendal, Norway.

出版信息

Scand J Rheumatol. 1993;22(5):229-32. doi: 10.3109/03009749309095128.

DOI:10.3109/03009749309095128

PMID:7901898

Abstract

Adverse reactions to sulphasalazine were seen in 35 of 100 patients with rheumatoid arthritis. Gastrointestinal side effects, skin reactions and increases of serum liver enzymes were most frequently noted. Serious or fatal adverse reactions were not observed. The frequency of toxicity to sulphasalazine was significantly lower among patients treated concurrently with small doses of oral corticosteroids, and also among cases seropositive for rheumatoid factors. Of the 14 seropositive patients also treated with corticosteroids, none developed side effects to sulphasalazine.

摘要

100例类风湿性关节炎患者中有35例出现了对柳氮磺胺吡啶的不良反应。最常注意到的是胃肠道副作用、皮肤反应和血清肝酶升高。未观察到严重或致命的不良反应。在同时接受小剂量口服皮质类固醇治疗的患者中，以及在类风湿因子血清阳性的病例中，柳氮磺胺吡啶的毒性发生率显著较低。在14例同时接受皮质类固醇治疗的血清阳性患者中，没有一例出现柳氮磺胺吡啶的副作用。