Solari R, Morris B, Morris R
Biol Neonate. 1984;46(4):163-70. doi: 10.1159/000242061.
A 0.2-ml dose containing 500 micrograms labelled rat IgG saturated the receptor-mediated transport system of the enterocytes of the jejunum of the small intestine. At subsaturation dose levels very little intracellular digestion of IgG occurred--the intact transport system was primarily employed. The uptake of IgG by enterocytes, at doses above saturation, was assessed over periods up to 6 h. There was an initial phase of rapid intracellular digestion by the enterocytes, followed by a much longer period during which the receptor-mediated transport system discharged intact IgG into the vascular compartment. The observations are discussed in the light of recent evidence relating to the numbers of IgG receptors on jejunal enterocytes.
含有500微克标记大鼠免疫球蛋白的0.2毫升剂量饱和了小肠空肠肠细胞的受体介导转运系统。在亚饱和剂量水平时，免疫球蛋白的细胞内消化很少发生——主要利用的是完整的转运系统。在长达6小时的时间段内评估了高于饱和剂量时肠细胞对免疫球蛋白的摄取情况。首先是肠细胞进行快速细胞内消化的初始阶段，随后是更长的一段时间，在此期间受体介导的转运系统将完整的免疫球蛋白释放到血管腔中。根据最近有关空肠肠细胞上免疫球蛋白受体数量的证据对这些观察结果进行了讨论。
