Bassermann R, Arnholdt H, Berg D
Geburtshilfe Frauenheilkd. 1984 Sep;44(9):566-9. doi: 10.1055/s-2008-1036303.
During a twin pregnancy of a 41-year old woman, a selective sectio parva was performed, without removing the placenta, in the 23rd week of gestation. An amniotic fluid examination after routine amniocentesis showed a free trisomy 21 in only one of the twins. The twin with normal caryotype was delivered in the 28th week. His placenta was well developed, whereas the placenta of the other child showed severe obliterations of the stem arteries with partial avascularity of the villi. The histological aspect was that of a so-called "endarteritis obliterans". Since the twin delivered via sectio parva showed no signs of dystrophy, we presume that at the time of delivery his placenta had developed regularly. The changes of the placenta, demonstrated by histological examinations, seemed to be caused by the stopping of the foetal blood circulation. We suggest that the intrauterine death is not caused by "endarteritis obliterans" only as often described previously. Obviously, the morphological picture of endarteritis obliterans can be the result of cessation of foetal blood circulation. Obliteration of stem arteries might be the main reason for the stillbirth with significant signs of dystrophy. The similar histological picture in placentae of normally developed stillbirths is obviously caused by discontinuation of foetal blood circulation.
在一名41岁女性的双胎妊娠中,于妊娠23周时进行了选择性小剖宫术,未取出胎盘。常规羊膜腔穿刺术后的羊水检查显示,仅其中一个胎儿为21三体游离型。核型正常的胎儿于28周时娩出。其胎盘发育良好,而另一个胎儿的胎盘显示主干动脉严重闭塞,绒毛部分无血管。组织学表现为所谓的“闭塞性动脉内膜炎”。由于经小剖宫术娩出的胎儿未出现营养不良的迹象,我们推测在分娩时其胎盘发育正常。组织学检查显示的胎盘变化似乎是由胎儿血液循环停止所致。我们认为,宫内死亡并非如先前常描述的那样仅由“闭塞性动脉内膜炎”引起。显然,闭塞性动脉内膜炎的形态学表现可能是胎儿血液循环停止的结果。主干动脉闭塞可能是伴有明显营养不良体征的死产的主要原因。正常发育的死产胎盘的类似组织学表现显然是由胎儿血液循环中断引起的。