Gerber M
Radiat Res. 1984 Nov;100(2):365-77.
A biphasic curve was observed when surviving allogeneic lytic activity was plotted as a function of irradiation delivered before sensitization. Flow cytometry analysis demonstrated that the number of cells was reduced in response to increasing dose and that subset precursors Lyt 1+2+ were proportionally more radiosensitive than the other subsets. Paradoxically, the presence of exogenous T-cell growth factor (TCGF) in limiting dilution analysis changed the shape of the survival curve, and the mere addition of TCGF or Lyt 2- TCGF-producing cells abrogated the irradiation effect even though they were not shown to be the target of low dose irradiation in flow cytometry analysis. It is proposed that TCGF acted by enhancing the proliferation of surviving cells. This effect may be responsible for the relative radioresistance at higher doses due to enhanced availability of TCGF for the remaining cells.
当将存活的同种异体溶解活性作为致敏前给予的照射剂量的函数进行绘制时，观察到一条双相曲线。流式细胞术分析表明，细胞数量随着剂量增加而减少，并且亚群前体Lyt 1+2+比其他亚群对辐射更敏感。矛盾的是，在有限稀释分析中存在外源性T细胞生长因子（TCGF）改变了存活曲线的形状，并且仅仅添加TCGF或产生Lyt 2-TCGF的细胞就消除了辐射效应，尽管在流式细胞术分析中它们并未被证明是低剂量辐射的靶标。有人提出，TCGF通过增强存活细胞的增殖而起作用。由于剩余细胞可获得的TCGF增加，这种效应可能是导致较高剂量时相对抗辐射性的原因。
