Velikiĭ N N
Ukr Biokhim Zh (1978). 1984 Jul-Aug;56(4):369-83.
Data are analyzed on a regulatory effect of the redox state of NAD- and NADP-couples (the free NAD+-/NADH, NADP+/NADPH ratios) on certain enzymic links of lipogenesis. A concept is formulated on coordination of the activity of lipogenesis key enzymes by a common signal, supposedly by changes in the NAD+/NADH and NADP+/NADPH values in cytoplasm and mitochondria of the rat liver cells. High values of the NAD- and NADP-couples ratios, activation of the citrate transport from mitochondria to cytoplasm and of enzymic systems supplying lipogenesis with a substrate--acetyl-CoA, reducing equivalents (NADPH) determine the maximal lipid synthesis rate observed in adaptive hyperlipogenesis. The inhibitory action of nicotinamide on lipogenesis is realized at the level of systems providing a high metabolic pool of acetyl-CoA and dehydrogenases, producing NADPH in cytoplasm of liver cells.
对NAD和NADP偶联的氧化还原状态（游离NAD⁺/NADH、NADP⁺/NADPH比值）对脂肪生成某些酶促环节的调节作用进行了数据分析。提出了一个概念，即脂肪生成关键酶的活性通过一个共同信号进行协调，推测该信号是大鼠肝细胞细胞质和线粒体中NAD⁺/NADH和NADP⁺/NADPH值的变化。NAD和NADP偶联比值的高值、柠檬酸从线粒体向细胞质的转运激活以及为脂肪生成提供底物——乙酰辅酶A、还原当量（NADPH）的酶系统激活，决定了适应性高脂生成中观察到的最大脂质合成速率。烟酰胺对脂肪生成的抑制作用在为乙酰辅酶A提供高代谢库的系统以及在肝细胞细胞质中产生NADPH的脱氢酶水平上得以实现。
