Burnett J C, Granger J P, Opgenorth T J
Am J Physiol. 1984 Nov;247(5 Pt 2):F863-6. doi: 10.1152/ajprenal.1984.247.5.F863.
Studies were performed in anesthetized dogs (n = 5) to determine the effects of synthetic atrial natriuretic factor on renal function and renin release. Intrarenal infusion of synthetic atrial natriuretic factor (ANF) (0.3 microgram X kg-1 X min-1) resulted in a transient increase in renal blood flow (126 +/- 8 to 148 +/- 11 ml/min). The duration of this transient vasodilation was 3.1 +/- 0.4 min. Continued infusion was followed by a slight decrease in renal blood flow (126 +/- 8 to 117 +/- 8 ml/min) and an increase in glomerular filtration rate (23.1 +/- 3.5 to 30.7 +/- 1.9 ml/min), with filtration fraction thus being increased (0.19 +/- 0.04 to 0.27 +/- 0.03). These hemodynamic alterations were associated with increases in fractional sodium excretion (0.6 +/- 0.2 to 5.8 +/- 0.8%), fractional potassium excretion (30.8 +/- 9.4 to 56.3 +/- 7.4%), fractional lithium excretion (32.2 +/- 7.1 to 60.3 +/- 5.7%), and fractional phosphate excretion (8.7 +/- 3.5 to 41.6 +/- 11.7%). Intrarenal infusion of synthetic ANF markedly suppressed renin secretion rate (295.5 +/- 84.6 to 17.2 +/- 10.6 ng/min) despite a slight reduction in arterial pressure (123 +/- 9 to 118 +/- 9 mmHg). Our studies demonstrate that synthetic ANF results in a marked natriuretic response that is in part mediated by an increase in glomerular filtration rate. The increase in fractional lithium and phosphate excretion suggests that this factor may also have an action on proximal tubule reabsorption. Further, these studies demonstrate that synthetic ANF markedly inhibits renin secretion.
对5只麻醉犬进行了研究，以确定合成心房利钠因子对肾功能和肾素释放的影响。肾内输注合成心房利钠因子（ANF）（0.3微克×千克⁻¹×分钟⁻¹）导致肾血流量短暂增加（从126±8毫升/分钟增加到148±11毫升/分钟）。这种短暂血管舒张的持续时间为3.1±0.4分钟。持续输注后，肾血流量略有下降（从126±8毫升/分钟降至117±8毫升/分钟），肾小球滤过率增加（从23.1±3.5毫升/分钟增至30.7±1.9毫升/分钟），滤过分数因此增加（从0.19±0.04增至0.27±0.03）。这些血流动力学改变与钠排泄分数增加（从0.6±0.2%增至5.8±0.8%）、钾排泄分数增加（从30.8±9.4%增至56.3±7.4%）、锂排泄分数增加（从32.2±7.1%增至60.3±5.7%）以及磷酸盐排泄分数增加（从8.7±3.5%增至41.6±11.7%）相关。尽管动脉压略有降低（从123±9毫米汞柱降至118±9毫米汞柱），肾内输注合成ANF仍显著抑制肾素分泌率（从295.5±84.6纳克/分钟降至17.2±10.6纳克/分钟）。我们的研究表明，合成ANF会导致显著的利钠反应，部分是由肾小球滤过率增加介导的。锂和磷酸盐排泄分数的增加表明该因子可能对近端小管重吸收也有作用。此外，这些研究表明合成ANF显著抑制肾素分泌。
