Luk'ianenko N G, Bogatskiĭ A V, Iaroshenko I M, Vongaĭ V G, Nazarov E I
Farmakol Toksikol. 1984 Sep-Oct;47(5):29-32.
The authors studied antiarrhythmic properties of macrocyclic polyesters. Some of the esters exhibited antiarrhythmic activity coupled with low toxicity. It was found that antiarrhythmic action of these substances is not mediated via acetylcholine and/or catecholamine system responsible for nervous regulation of the cardiac activity. The compounds under study were found to have marked antifibrillar properties. Experiments on an isolated rat heart demonstrated calcium specificity of the antifibrillar action of cyclolactones. It is assumed that macrocyclic polyesters represent a new class of antiarrhythmic agents having a direct cardiotropic action.
作者们研究了大环聚酯的抗心律失常特性。其中一些酯类表现出抗心律失常活性且毒性较低。研究发现，这些物质的抗心律失常作用并非通过负责心脏活动神经调节的乙酰胆碱和/或儿茶酚胺系统介导。研究中的化合物被发现具有显著的抗纤颤特性。在离体大鼠心脏上进行的实验证明了环内酯抗纤颤作用的钙特异性。据推测，大环聚酯代表了一类具有直接心脏作用的新型抗心律失常药物。
