Almond R E, Enser M
Diabetologia. 1984 Sep;27(3):407-13. doi: 10.1007/BF00304859.
The histochemical and morphological characteristics of muscles from lean and obese hyperglycaemic ob/ob mice were compared to determine the nature of the low skeletal muscle mass of the latter. Gastrocnemius and biceps brachii muscles from obese ob/ob mice were significantly lighter than those from lean mice, whereas the weights of soleus muscles were not significantly different. The small mass of the biceps brachii muscle resulted from a decrease in diameter of the large glycolytic fast white and fast intermediate fibres and a reduction in the proportion of fast white fibres. The size and frequency of the more oxidative fast red fibres was not different. The histochemical appearance of all fibre types studied from muscles in obese mice was identical to equivalent fibres in lean mice. The fat content of muscles from obese mice was three times greater than in lean mice whereas muscle DNA concentration was similar.
比较了瘦型和肥胖型高血糖ob/ob小鼠肌肉的组织化学和形态学特征，以确定后者骨骼肌质量较低的本质。肥胖ob/ob小鼠的腓肠肌和肱二头肌明显比瘦型小鼠的轻，而比目鱼肌的重量没有显著差异。肱二头肌质量小是由于大型糖酵解快白肌纤维和快中间型纤维的直径减小以及快白肌纤维比例降低。氧化能力更强的快红肌纤维的大小和频率没有差异。肥胖小鼠肌肉中所有研究的纤维类型的组织化学外观与瘦型小鼠的相应纤维相同。肥胖小鼠肌肉的脂肪含量是瘦型小鼠的三倍，而肌肉DNA浓度相似。
