阿尔茨海默病、亨廷顿病和帕金森病中特定脑区的脑代谢关系。

Cerebral metabolic relationships for selected brain regions in Alzheimer's, Huntington's, and Parkinson's diseases.

作者信息

Metter E J, Riege W H, Kameyama M, Kuhl D E, Phelps M E

出版信息

J Cereb Blood Flow Metab. 1984 Dec;4(4):500-6. doi: 10.1038/jcbfm.1984.74.

DOI:10.1038/jcbfm.1984.74

Abstract

Local CMRGlc values were determined for 13 regions in each hemisphere from tomographs of patients with Alzheimer's, Huntington's, and Parkinson's diseases who were studied using [18F]fluorodeoxyglucose with positron emission computed tomography. Intercorrelations among the 26 regional measures were calculated for each disease state and for normal controls, and were accepted as reliable at p less than 0.01, uncorrected for the number of comparisons. The number of reliable correlations was found to be decreased in Parkinson's and Huntington's diseases, two primarily subcortical disorders, and increased in Alzheimer's disease, a primarily cortical disorder. The changes suggest that one role of the basal ganglia involves coordinating or pacing the ability of cortical brain regions to function as a unit.

摘要

通过正电子发射计算机断层扫描使用[18F]氟脱氧葡萄糖对患有阿尔茨海默病、亨廷顿病和帕金森病的患者进行断层扫描，测定每个半球13个区域的局部CMRGlc值。针对每种疾病状态和正常对照组计算26个区域测量值之间的相互关系，在未对比较次数进行校正的情况下，p值小于0.01时被认为是可靠的。结果发现，在主要为皮质下疾病的帕金森病和亨廷顿病中，可靠相关性的数量减少；而在主要为皮质疾病的阿尔茨海默病中，可靠相关性的数量增加。这些变化表明，基底神经节的一个作用是协调或调节大脑皮质区域作为一个整体发挥功能的能力。