母体和新生儿人淋巴细胞混合培养物中单核细胞趋化因子的产生

Monocyte chemotactic factor production in mixed cultures of maternal and neonatal human lymphocytes.

作者信息

Hawes C S, Kemp A S, Jones W R

出版信息

J Reprod Immunol. 1984 Jul;6(4):261-5. doi: 10.1016/0165-0378(84)90014-7.

Abstract

The immunological interaction between related maternal and neonatal human lymphocytes was investigated by assaying monocyte chemotactic factor production in mixed cell culture. Lymphokine was detected in a significantly lower proportion of maternal-neonatal cell cultures compared to mixed cultures of cells from unrelated adults and/or neonates. It is possible that a reduced inflammatory mediator production at the feto-maternal interface may contribute to the survival of the fetal allograft.

摘要

通过检测混合细胞培养物中单核细胞趋化因子的产生，研究了母体和新生儿相关人类淋巴细胞之间的免疫相互作用。与来自无关成年人和/或新生儿的细胞混合培养物相比，在母婴细胞培养物中检测到淋巴因子的比例显著降低。胎儿-母体界面处炎症介质产生的减少可能有助于胎儿同种异体移植物的存活。