Rohrer T F, Pfister B, Weber C, Imhof P R, Stucki P
Blut. 1978 Jan 20;36(1):21-6. doi: 10.1007/BF01002116.
Quantitative measurements of platelet aggregation in samples of venous blood were made in altogether 66 healthy volunteers by a modified version of the method of Wu and Hoak. The formation of aggregates was found to be unaffected or at the most barely affected by such factors as sex, age, smoking, fatty food, physical exertion and medication with isoprenaline or ovulation inhibitors. No difference in the number of aggregates formed was noted between 12 control patients and 16 patients with myocardial infarcts or 14 with other conditions predisposing to arterial thrombosis. Anticoagulant therapy had no effect on aggregation. It is suspected that aggregation in vitro due to methodological factors may obscure any quantitative alterations in the formation of aggregation present in vivo.
采用改良的吴和霍克方法，对66名健康志愿者的静脉血样本进行了血小板聚集的定量测量。结果发现，聚集物的形成不受性别、年龄、吸烟、高脂饮食、体育锻炼以及使用异丙肾上腺素或排卵抑制剂等因素的影响，或至多受到轻微影响。12名对照患者、16名心肌梗死患者和14名患有其他易导致动脉血栓形成疾病的患者之间，形成的聚集物数量没有差异。抗凝治疗对聚集没有影响。有人怀疑，由于方法学因素导致的体外聚集可能掩盖了体内聚集形成过程中存在的任何定量变化。
