Davis J W, Phillips P E, Lewis H D, Davis R F
Postgrad Med J. 1981 Mar;57(665):150-2. doi: 10.1136/pgmj.57.665.150.
The platelet aggregate ratio has been found to be decreased in some patients with vascular diseases suggesting the presence of increased circulating platelet aggregates. It has also been reported that hypercholesterolaemia is associated with an enhanced response of platelets to aggregating agents in platelet-rich plasma. The primary purpose of this investigation was to determine correlation of the platelet aggregate ratio with the serum cholesterol concentration of men with vascular diseases. For 52 men referred because of known or suspected coronary artery disease, cerebrovascular disease, or venous thromboembolism, the correlation coefficient of 0·06 suggested that the serum cholesterol concentration within the range observed (135-360 mg/dl) was not a factor influencing the platelet aggregate ratio. There was not a statistically significant difference between the mean platelet aggregate ratios or the mean serum cholesterol concentrations of the 21 non-smokers and the 31 smokers studied. A correlation coefficient of 0·03 between the platelet aggregate ratio and age of the patient suggested that the platelet aggregate ratio was independent of age in men with occlusive vascular diseases.
已发现一些血管疾病患者的血小板聚集率降低，这表明循环中的血小板聚集体增加。也有报道称，高胆固醇血症与富含血小板血浆中血小板对聚集剂的反应增强有关。本研究的主要目的是确定血管疾病男性患者的血小板聚集率与血清胆固醇浓度之间的相关性。对于因已知或疑似冠状动脉疾病、脑血管疾病或静脉血栓栓塞而转诊的52名男性患者，0.06的相关系数表明，在所观察的血清胆固醇浓度范围（135 - 360mg/dl）内，血清胆固醇浓度不是影响血小板聚集率的因素。在研究的21名不吸烟者和31名吸烟者中，平均血小板聚集率或平均血清胆固醇浓度之间没有统计学上的显著差异。患者血小板聚集率与年龄之间的相关系数为0.03，这表明在患有闭塞性血管疾病的男性中，血小板聚集率与年龄无关。
