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[人类白细胞分化抗原]

[Human leukocyte differentiation antigens].

作者信息

Bernard A, Boumsell L

出版信息

Presse Med. 1984 Oct 27;13(38):2311-6.

PMID:6239187
Abstract

Over a small number of years many monoclonal antibodies directed against leucocytes have been produced. Their multiplicity and the various nomenclatures utilized may be disconcerting. As a result of the First International Workshop on Human Leucocyte Differentiation Antigens (Paris, 1982), a very clear correspondence between these different antibodies has been established by regrouping into "differentiation classes", each class corresponding to a given molecular species at leucocyte surface. One of the consequences of this international co-operative study has been the development of a nomenclature system now officially adopted by the World Health Organization. In addition, it is now possible to identify the general characteristics of leucocyte surface molecules, which provides information on their organization and function. The international study is in progress, and the results of the Second Workshop (Boston, 1984) will soon be available.

摘要

在过去几年里,已经产生了许多针对白细胞的单克隆抗体。它们的多样性以及所使用的各种命名法可能令人困惑。由于第一届人类白细胞分化抗原国际研讨会(1982年,巴黎),通过重新组合为“分化类别”,已在这些不同抗体之间建立了非常明确的对应关系,每个类别对应白细胞表面的一种特定分子类型。这项国际合作研究的成果之一是开发了一种命名系统,该系统现已被世界卫生组织正式采用。此外,现在有可能确定白细胞表面分子的一般特征,这提供了有关其结构和功能的信息。国际研究正在进行中,第二届研讨会(1984年,波士顿)的结果即将公布。

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