Bazzan M, Pannocchia A, Schinco P C, Della Dora N, Tamponi G
Acta Haematol. 1984;72(4):239-44. doi: 10.1159/000206396.
Platelet activation in vivo was studied in patients with thrombophlebitis of the lower limbs. The parameters considered were the platelet aggregate ratio (PAR) and the beta-thromboglobulin (beta-tg) level, which were repeatedly evaluated from the disease onset up to 3 months later, during anticoagulating and antiaggregating therapy. A significant decrease of PAR was found, along with a significant rise of the beta-tg level at the onset of the disease, and these values slowly returned to normal on therapy course. The same parameters exceeded the normal range again when the patients arbitrarily suspended any drug assumption. The possible significance and implications of these findings are discussed.
对下肢血栓性静脉炎患者体内的血小板活化情况进行了研究。所考虑的参数为血小板聚集率（PAR）和β-血小板球蛋白（β-tg）水平，在抗凝和抗聚集治疗期间，从疾病发作开始直至3个月后对这些参数进行了反复评估。发现疾病发作时PAR显著降低，同时β-tg水平显著升高，并且这些值在治疗过程中缓慢恢复正常。当患者随意停用任何药物时，相同参数再次超出正常范围。讨论了这些发现的可能意义和影响。
