Cella G, Zahavi J, de Haas H A, Kakkar V V
Br J Haematol. 1979 Sep;43(1):127-36. doi: 10.1111/j.1365-2141.1979.tb03727.x.
Plasma beta-thromboglobulin (beta TG) levels were measured in 103 healthy controls and 112 patients suffering from either peripheral vascular disease (PVD), or cerebrovascular disease (CVD) or deep vein thrombosis (DVT). Plasma beta TG was significantly elevated in 46 PVD patients and 24 recent DVT patients compared to controls, but did not differ significantly in 18 chronic DVT and 24 old CVD patients. In addition, heparin neutralizing activity (HNA) and platelet aggregation induced by adenosine diphosphate, 1-epinephrine and thrombin were compared in 33 out of the 46 PVD patients to 33 controls. The mean HNA was significantly shorter in the PVD patients than in controls. The rate and extent of platelet aggregation were increased in PVD patients compared to controls, but the difference was not statistically significant. Platelet production time (PPT) was measured in 20 controls, 35 PVD patients, nine chronic DVT and 12 chronic CVD patients; significantly shorter PPT was only observed in 14 patients with advanced PVD compared to controls, suggesting increased platelet consumption in these patients. All four assays (plasma beta TG, HNA, platelet aggregation and PPT) were performed in 25 patients; no correlation between the four tests was found in these patients suggesting that the tests were measuring various aspects of platelet function. These results suggest that in vivo platelet consumption as well as platelet aggregation and 'release reaction' are presumably enhanced in PVD and recent DVT patients and that plasma beta TG and PPT assays may be better and more specific indicators of in vivo platelet activation than in vitro platelet aggregation test.
对103名健康对照者以及112名患有外周血管疾病（PVD）、脑血管疾病（CVD）或深静脉血栓形成（DVT）的患者测定了血浆β-血小板球蛋白（β-TG）水平。与对照组相比，46名PVD患者和24名近期DVT患者的血浆β-TG显著升高，但18名慢性DVT患者和24名陈旧性CVD患者的血浆β-TG无显著差异。此外，对46名PVD患者中的33名与33名对照者比较了肝素中和活性（HNA）以及由二磷酸腺苷、肾上腺素和凝血酶诱导的血小板聚集情况。PVD患者的平均HNA显著短于对照者。与对照者相比，PVD患者血小板聚集的速率和程度有所增加，但差异无统计学意义。对20名对照者、35名PVD患者、9名慢性DVT患者和12名慢性CVD患者测定了血小板生成时间（PPT）；与对照者相比，仅在14名晚期PVD患者中观察到显著缩短的PPT，提示这些患者的血小板消耗增加。对25名患者进行了所有四项检测（血浆β-TG、HNA、血小板聚集和PPT）；在这些患者中未发现四项检测之间存在相关性，提示这些检测在测量血小板功能的不同方面。这些结果表明，在PVD和近期DVT患者中，体内血小板消耗以及血小板聚集和“释放反应”可能增强，并且血浆β-TG和PPT检测可能比体外血小板聚集试验更好、更特异的体内血小板活化指标。
