Robertson D B, Kubiak E, Gomez E C
Br J Dermatol. 1984 Dec;111(6):689-94. doi: 10.1111/j.1365-2133.1984.tb14152.x.
Multiple polypoid projections of granulation tissue developed in two patients receiving isotretinoin for acne. Histological study of the lesions revealed increased amounts of non-sulphated acid mucopolysaccharides in the ground substance of the granulation tissue stroma. Complete resolution occurred following curettage with or without chemical cautery. The role of isotretinoin in the development of these lesions is discussed.
两名因痤疮接受异维甲酸治疗的患者出现了多个肉芽组织的息肉样突起。对这些病变的组织学研究显示，肉芽组织基质的基质中非硫酸化酸性粘多糖的含量增加。无论是否进行化学烧灼，刮除术后病变均完全消退。本文讨论了异维甲酸在这些病变发生过程中的作用。
