异维A酸治疗期间的化脓性肉芽肿。
Pyogenic granulomas during isotretinoin therapy.
作者信息
Armstrong Kathleen, Weinstein Miriam
机构信息
Paediatric Dermatology Hospital For Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8.
出版信息
J Dermatol Case Rep. 2011 Mar 26;5(1):5-7. doi: 10.3315/jdcr.2011.1062.
Abstract
BACKGROUND
A review of scientific literature reveals a sparse documentation of periungual pyogenic granulomas as an adverse effect of isotretinoin therapy
MAIN OBSERVATIONS
Periungual pyogenic granulomas appeared in four patients receiving isotretinoin therapy for severe acne. Oral and topical antibiotic treatments were ineffective and all cases spontaneously resolved once isotretinoin is discontinued.
CONCLUSION
This report demonstrates the idiosyncratic nature of this side effect. We suggest that, although infection is possible due to the transformed nature of the normally protective skin barrier, oral and topical antibiotic treatments appear ineffective. Pyogenic granulomas spontaneously resolve once isotretinoin is discontinued.
摘要
背景
对科学文献的回顾显示，关于异维A酸治疗的不良反应中，甲周化脓性肉芽肿的记录稀少。
主要观察结果
4例接受异维A酸治疗重度痤疮的患者出现了甲周化脓性肉芽肿。口服和外用抗生素治疗无效，一旦停用异维A酸，所有病例均自行消退。
结论
本报告证明了这种副作用的特异性。我们认为，尽管由于正常保护性皮肤屏障的改变可能导致感染，但口服和外用抗生素治疗似乎无效。停用异维A酸后，化脓性肉芽肿会自行消退。
相似文献
1
Pyogenic granulomas during isotretinoin therapy.异维A酸治疗期间的化脓性肉芽肿。
J Dermatol Case Rep. 2011 Mar 26;5(1):5-7. doi: 10.3315/jdcr.2011.1062.
2
Development of Periungual Pyogenic Granuloma with Associated Paronychia Following Isotretinoin Therapy: A Case Report and a Review of the Literature.异维A酸治疗后伴甲沟炎的甲周化脓性肉芽肿的发生：一例报告及文献复习
J Clin Aesthet Dermatol. 2019 Apr;12(4):32-36. Epub 2019 Apr 1.
3
Paronychia and granulation tissue formation during treatment with isotretinoin.异维A酸治疗期间的甲沟炎和肉芽组织形成。
An Bras Dermatol. 2016 Apr;91(2):223-5. doi: 10.1590/abd1806-4841.20163817.
4
Acitretin-induced periungual pyogenic granulomas and review.阿维 A 致甲周脓性肉芽肿及其文献复习
Dermatol Online J. 2021 Jul 15;27(7). doi: 10.5070/D327754369.
5
Pyogenic granuloma-like acne lesions during isotretinoin therapy.异维A酸治疗期间出现的化脓性肉芽肿样痤疮皮损
Arch Dermatol. 1983 Oct;119(10):808-11.
6
Eruptive pyogenic granulomas and acne fulminans in two siblings treated with isotretinoin. A possible common pathogenesis.异维A酸治疗的两名同胞兄妹中的发疹性化脓性肉芽肿和暴发性痤疮。一种可能的共同发病机制。
Dermatologica. 1988;177(1):16-8. doi: 10.1159/000248496.
7
Are topical beta-blockers really effective "in real life" for targeted therapy-induced paronychia.局部使用β受体阻滞剂在靶向治疗诱导性甲周炎的“真实生活”中真的有效吗？
Support Care Cancer. 2019 Jul;27(7):2341-2343. doi: 10.1007/s00520-019-04690-8. Epub 2019 Mar 7.
8
Assessment of the efficacy and safety of a combination of 2 topical retinoids (RetinSphere) in maintaining post-treatment response of acne to oral isotretinoin.评估两种外用维甲酸（RetinSphere）联合使用在维持痤疮口服异维A酸治疗后疗效方面的有效性和安全性。
Actas Dermosifiliogr. 2015 Mar;106(2):126-32. doi: 10.1016/j.ad.2014.09.001. Epub 2014 Oct 11.
9
Facial pyogenic granuloma-like lesions under isotretinoin therapy.异维A酸治疗下的面部化脓性肉芽肿样病变
Int J Dermatol. 1992 Mar;31(3):199-200. doi: 10.1111/j.1365-4362.1992.tb03936.x.
10
Efficacy of topical beta-blockers in the management of EGFR-inhibitor induced paronychia and pyogenic granuloma-like lesions: case series and review of the literature.局部用β受体阻滞剂治疗表皮生长因子受体抑制剂引起的甲沟炎和化脓性肉芽肿样病变的疗效：病例系列及文献综述
Drugs Context. 2019 Nov 6;8:212613. doi: 10.7573/dic.212613. eCollection 2019.
引用本文的文献
1
Nail changes in patients receiving systemic isotretinoin therapy.接受全身用异维 A 酸治疗的患者的指甲变化。
Sci Rep. 2024 Oct 26;14(1):25561. doi: 10.1038/s41598-024-77185-0.
2
Deep Seated Lobular Capillary Hemangioma (Pyogenic Granuloma) of the Colon: A Rare Case Requiring Surgery beyond Endoscopic Management.结肠深部小叶状毛细血管瘤（脓性肉芽肿）：1例罕见病例，需内镜治疗以外的手术治疗
Case Rep Pathol. 2022 Mar 29;2022:5641608. doi: 10.1155/2022/5641608. eCollection 2022.
3
Trachyonychia Secondary to Acitretin Usage.阿维A治疗继发的甲纵嵴
Cureus. 2020 Jan 19;12(1):e6703. doi: 10.7759/cureus.6703.
4
Acne and craniofacial defects.痤疮与颅面缺损。
JAAD Case Rep. 2019 May 31;5(6):495-497. doi: 10.1016/j.jdcr.2019.04.008. eCollection 2019 Jun.
5
Development of Periungual Pyogenic Granuloma with Associated Paronychia Following Isotretinoin Therapy: A Case Report and a Review of the Literature.异维A酸治疗后伴甲沟炎的甲周化脓性肉芽肿的发生：一例报告及文献复习
J Clin Aesthet Dermatol. 2019 Apr;12(4):32-36. Epub 2019 Apr 1.
6
Pyogenic Granuloma in an Atypical Location Following Isotretinoin Treatment.异维A酸治疗后非典型部位的化脓性肉芽肿
Sultan Qaboos Univ Med J. 2018 Aug;18(3):e409-e410. doi: 10.18295/squmj.2018.18.03.028. Epub 2018 Dec 19.
本文引用的文献
1
Periungual and subungual pyogenic granuloma.甲周和甲下化脓性肉芽肿。
Br J Dermatol. 2010 Nov;163(5):941-53. doi: 10.1111/j.1365-2133.2010.09906.x.
2
Paronychia and pyogenic granuloma-like lesions with isotretinoin.
J Am Acad Dermatol. 1984 Apr;10(4):677-8. doi: 10.1016/s0190-9622(84)80289-3.
3
Excess granulation tissue responses associated with isotretinoin therapy.与异维A酸治疗相关的过度肉芽组织反应。
Br J Dermatol. 1984 Dec;111(6):689-94. doi: 10.1111/j.1365-2133.1984.tb14152.x.
4
Retinoid therapy is associated with excess granulation tissue responses.
J Am Acad Dermatol. 1983 Nov;9(5):708-13. doi: 10.1016/s0190-9622(83)70184-2.
5
Isotretinoin treatment of acne and related disorders: an update.异维A酸治疗痤疮及相关疾病：最新进展
J Am Acad Dermatol. 1983 Oct;9(4):629-38. doi: 10.1016/s0190-9622(83)70176-3.
6
Etretinate and the nails (study of 130 cases) possible mechanisms of some side-effects.
Clin Exp Dermatol. 1986 Mar;11(2):148-52. doi: 10.1111/j.1365-2230.1986.tb00439.x.
7
Adverse reactions to isotretinoin. A report from the Adverse Drug Reaction Reporting System.
J Am Acad Dermatol. 1988 Mar;18(3):543-52. doi: 10.1016/s0190-9622(88)70078-x.
8
Granulation tissue proliferation during isotretinoin treatment.异维A酸治疗期间的肉芽组织增生。
Int J Dermatol. 1986 Apr;25(3):191-3. doi: 10.1111/j.1365-4362.1986.tb02218.x.
9
Facial pyogenic granuloma-like lesions under isotretinoin therapy.异维A酸治疗下的面部化脓性肉芽肿样病变
Int J Dermatol. 1992 Mar;31(3):199-200. doi: 10.1111/j.1365-4362.1992.tb03936.x.
Zotero 插件