Mackenzie R A, Creasey H, Huang C Y
Clin Exp Neurol. 1983;19:139-46.
Fifteen subjects with Down's syndrome had measurements of peripheral and central nervous system conduction parameters. Conventional nerve conduction studies revealed evidence of peripheral nerve dysfunction consistent with an axonal degeneration. Upper limb somatosensory evoked potentials were delayed compared with age-matched controls in both young and older age groups of Down's subjects. Lower limb somatosensory evoked potentials were also delayed when correction for height was made; furthermore the 'central conduction time' was prolonged in young and older groups. These results suggest that both peripheral and central nervous system function is impaired in Down's syndrome and the pattern of change is similar to that found with aging in normal individuals.
对15名唐氏综合征患者进行了外周和中枢神经系统传导参数测量。传统的神经传导研究显示存在与轴索性变性相符的外周神经功能障碍证据。与年龄匹配的对照组相比，唐氏综合征患者的年轻组和老年组上肢体感诱发电位均延迟。在对身高进行校正后，下肢体感诱发电位也延迟；此外，年轻组和老年组的“中枢传导时间”均延长。这些结果表明，唐氏综合征患者的外周和中枢神经系统功能均受损，且变化模式与正常个体衰老时相似。
