Agathos M, Remien C, Mutzeck E
Derm Beruf Umwelt. 1984;32(5):157-60.
Though infection with herpes simplex virus is one of the most common infections, there has not been causal topical treatment until now. Since 1973 tromantadine HCl (in the following briefly called tromantadine) has been offered as a topical virustatic agent. Only three years later, in 1976, there were the first reports of allergic contact dermatitis due to tromantadine. 19 patients with dermatitis after application of tromantadine ointment were patch-tested and in 14 of them a contact allergy to tromantadine was observed. In 119 patients who were patch-tested because of various dermatoses, tromantadine and the gel base were patch-tested additionally. Two positive reactions to the active substance and two to the gel base only were found. One of the latter patients also had a positive reaction to parabens. The results are discussed and compared with the results of other authors.
尽管单纯疱疹病毒感染是最常见的感染之一，但迄今为止尚无针对性的局部治疗方法。自1973年以来，盐酸曲金刚胺（以下简称曲金刚胺）一直作为一种局部抗病毒剂使用。仅三年后的1976年，就首次有关于曲金刚胺引起过敏性接触性皮炎的报道。对19例使用曲金刚胺软膏后出现皮炎的患者进行了斑贴试验，其中14例观察到对曲金刚胺的接触性过敏。在119例因各种皮肤病接受斑贴试验的患者中，还对曲金刚胺及其凝胶基质进行了斑贴试验。仅发现2例对活性物质呈阳性反应，2例仅对凝胶基质呈阳性反应。后一组患者中有1例对防腐剂也呈阳性反应。对结果进行了讨论，并与其他作者的结果进行了比较。
