Allergic contact dermatitis from tromantadine.

Tromantadine is a topical antiviral agent derived from amantadine. In previous reports, 5% of treated patients developed contact allergy. We report the case of a 28-year-old woman who had a sudden worsening of a lip herpes after treatment with a tromantadine ointment, with strong positive patch testing to this substance. The purpose of this paper is to call attention to the fact that tromantadine is still widely used in several European countries as a second-line therapy for lip herpes, and therefore, new cases of sensitization to tromantadine are likely to occur.