Jáuregui I, Urrutia I, Gamboa P M, Antépara I
Allergology Section, Hospital de Basurto, Bilbao, Spain.
J Investig Allergol Clin Immunol. 1997 Jul-Aug;7(4):260-1.
Tromantadine is a topical antiviral agent derived from amantadine. In previous reports, 5% of treated patients developed contact allergy. We report the case of a 28-year-old woman who had a sudden worsening of a lip herpes after treatment with a tromantadine ointment, with strong positive patch testing to this substance. The purpose of this paper is to call attention to the fact that tromantadine is still widely used in several European countries as a second-line therapy for lip herpes, and therefore, new cases of sensitization to tromantadine are likely to occur.
曲金刚胺是一种源自金刚烷胺的局部用抗病毒药。在既往报告中，5%的接受治疗患者发生了接触性过敏。我们报告一例28岁女性，在用曲金刚胺软膏治疗唇疱疹后病情突然恶化，对该物质的斑贴试验呈强阳性。本文旨在提醒注意，曲金刚胺在若干欧洲国家仍被广泛用作唇疱疹的二线治疗药物，因此，可能会出现新的曲金刚胺致敏病例。
