Elias A N, Hoefs J, Parker L, Haw T, Lifrak E T
Gen Pharmacol. 1984;15(5):427-30. doi: 10.1016/0306-3623(84)90044-2.
Short-term bile duct ligation in male rabbits resulted in a significant reduction in the rate of sodium excretion after saline challenge (10 ml/kg/hr for 4 hr, P less than 0.03). The reduction in the sodium excretory rate (14.3 +/- 7.8 to 6.3 +/- 5 mu-equiv/min, P less than 0.03) was associated with an increased urinary PGE2 excretion (200.9 +/- 174 to 731.8 +/- 1039.8 pg/min, P less than 0.01) without significant change in serum aldosterone and cortisol concentrations. Serum progesterone concentration increased (37.2 +/- 15.6 to 119.2 +/- 34.6 ng/dl, P less than 0.01) whereas serum 17-hydroxyprogesterone concentration declined after bile duct ligation suggesting the development of a 17-hydroxylase enzymatic block.
对雄性兔子进行短期胆管结扎后，在盐水输注（10毫升/千克/小时，持续4小时）刺激后，钠排泄率显著降低（P<0.03）。钠排泄率降低（从14.3±7.8降至6.3±5微当量/分钟，P<0.03）与尿中前列腺素E2排泄增加（从200.9±174增至731.8±1039.8皮克/分钟，P<0.01）相关，而血清醛固酮和皮质醇浓度无显著变化。胆管结扎后血清孕酮浓度升高（从37.2±15.6增至119.2±34.6纳克/分升，P<0.01），而血清17-羟孕酮浓度下降，提示出现17-羟化酶酶阻滞。
