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DNA-DNA and DNA-protein crosslinking and repair in Neurospora crassa following exposure to nitrogen mustard.

作者信息

Baker J M, Parish J H, Curtis J P

出版信息

Mutat Res. 1984 Nov-Dec;132(5-6):171-9. doi: 10.1016/0167-8817(84)90035-x.

DOI:10.1016/0167-8817(84)90035-x
PMID:6239978
Abstract

A new method was developed for the analysis of DNA-protein crosslinks in Neurospora crassa. The formations of DNA-protein and DNA-DNA crosslinks were assayed following exposure of spheroplasts to HN2. Both types of crosslink were detected and were found to be repaired during recovery. Moreover a mutant sensitive to HN2 was defective in the removal of both types of crosslink.

摘要

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