Plötz J, Schreiber W
Anaesthesist. 1984 Nov;33(11):548-51.
Intubation conditions, onset time (time from the end of the injection until the maximum twitch depression (1 Hz) of the adductor pollicis muscle) as well as changes in blood pressure and pulse rate were studied in a randomized double-blind study of 40 male patients (average age 69-70 years) anaesthetized with halothane following atracurium (ATR) 0.33 mg X kg-1 or alcuronium (DAN) 0.1 mg X kg-1. An additional group received succinylcholine (SCH) 1.0 mg X kg-1. Intubation conditions at the end of the onset time were slightly and significantly better after ATR than following DAN, in each case, however, distinctly worse than after SCH. The onset time amounted to 115.0 s after ATR and 125.0 s following DAN (48.6 s after SCH). Neither ATR nor DAN showed statistically significant effects on blood pressure or pulse. One bronchospastic reaction which responded to therapy was observed per group. ATR proved to be comparable to DAN in respect to effectiveness and safety.
在一项随机双盲研究中，对40例男性患者（平均年龄69 - 70岁）进行了研究，这些患者在接受氟烷麻醉后，分别注射阿曲库铵（ATR）0.33 mg/kg或阿库氯铵（DAN）0.1 mg/kg，另有一组接受琥珀胆碱（SCH）1.0 mg/kg。研究了插管条件、起效时间（从注射结束到拇内收肌最大抽搐抑制（1 Hz）的时间）以及血压和脉搏率的变化。在起效时间结束时，ATR后的插管条件略好于DAN，且差异具有统计学意义，但在每种情况下，均明显差于SCH后的插管条件。ATR后的起效时间为115.0秒，DAN后为125.0秒（SCH后为48.6秒）。ATR和DAN对血压或脉搏均无统计学意义上的显著影响。每组均观察到1例对治疗有反应的支气管痉挛反应。在有效性和安全性方面，ATR被证明与DAN相当。
