萘啶酸、恶喹酸、西诺沙星和诺氟沙星治疗尿路感染（UTI）的疗效及安全性经验。

Experiences on the efficacy and safety of nalidixic acid, oxolinic acid, cinoxacin and norfloxacin in the treatment of urinary tract infections (UTI).

作者信息

Sabbour M S, El Bokl M A, Osman L M

出版信息

Infection. 1984 Nov-Dec;12(6):377-80. doi: 10.1007/BF01645218.

Abstract

The purpose of this study was to determine the effectiveness and tolerability of norfloxacin, cinoxacin and oxolinic acid in the treatment of urinary tract infections (UTI) in comparison to nalidixic acid. 125 patients were given the drugs in the appropriate doses for 10-14 days and 30 patients were treated for six weeks. Clinical, bacteriological, hematological and chemical checks were made on all patients before and after treatment. It was found that norfloxacin, cinoxacin and oxolinic acid are safe and effective against Escherichia coli, Klebsiella and Proteus, the commonly encountered organisms in urinary tract infections. The cure rate for norfloxacin was 93%, for cinoxacin 83%, for oxolinic acid 80% and for nalidixic acid 70% in the short course. However, these differences were not statistically significant. Oxolinic acid, cinoxacin and norfloxacin have the advantage over nalidixic acid of being administered only twice daily.

摘要

本研究的目的是确定诺氟沙星、西诺沙星和恶喹酸与萘啶酸相比，在治疗尿路感染（UTI）方面的有效性和耐受性。125例患者接受适当剂量的药物治疗10 - 14天，30例患者接受六周治疗。在治疗前后对所有患者进行了临床、细菌学、血液学和化学检查。结果发现，诺氟沙星、西诺沙星和恶喹酸对尿路感染中常见的大肠杆菌、克雷伯菌和变形杆菌是安全有效的。在短疗程中，诺氟沙星的治愈率为93%，西诺沙星为83%，恶喹酸为80%，萘啶酸为70%。然而，这些差异无统计学意义。恶喹酸、西诺沙星和诺氟沙星比萘啶酸有每天只需给药两次的优势。