Sadun A A, Smythe B A, Schaechter J D
J Clin Neuroophthalmol. 1984 Dec;4(4):265-73.
An elderly woman was admitted to the hospital with a presumptive diagnosis of optic neuritis following abrupt loss of vision in her left eye. Noninvasive studies were unrevealing, and she was put on a course of prednisone. Further visual loss 2 weeks later prompted a second course of prednisone therapy. Six years later the patient died from cardiac arrest. The autopsy revealed an aneurysm arising from the origin of the left ophthalmic artery. Selected brain specimens were histologically examined by application of a newly developed staining technique capable of identifying degenerated axons in human brain tissue even after long survival periods. We traced degeneration from the site of compression at the left optic nerve to five primary visual nuclei. Furthermore, transsynaptic cellular changes were observed in the lateral geniculate nucleus.
一名老年女性因左眼突然失明被收治入院，初步诊断为视神经炎。无创检查未发现异常，遂给予泼尼松治疗。两周后视力进一步下降，促使进行第二轮泼尼松治疗。六年后，患者死于心脏骤停。尸检发现左眼动脉起始处有一个动脉瘤。应用一种新开发的染色技术对选定的脑标本进行组织学检查，该技术即使在长时间存活后也能识别出人类脑组织中退化的轴突。我们追踪了从左侧视神经受压部位到五个主要视觉核的退化情况。此外，在外侧膝状核中观察到了跨突触细胞变化。
