Delmas P D, Meunier P J
Rev Med Interne. 1984 Nov;5(4):363-6. doi: 10.1016/s0248-8663(84)80015-6.
The diphosphonates (DP) represent a new class of therapeutic agents, the main property of which is to block bone resorption, irrespective of its stimulus. Apart from their remarkable results in Paget's disease of the bone, DP are very effective in the treatment of hypercalcaemia the osseus origin of which is nearly always essential. In malignant hypercalcaemia, EHDP, C12 MDP and APD, the three DP tested in man, cause a fall in serum calcium in a few days when administered intravenously. The latter two preparations are also effective when given orally. DP are also valuable in controlling hypercalcaemia in primary hyperparathyroidism. Research is under way to determine the role of DP in the prevention of malignant osteolysis, as distinct from the effects of chemotherapy.
双膦酸盐（DP）是一类新型治疗药物，其主要特性是不论刺激因素如何，均可阻断骨吸收。除了在骨Paget病中取得显著疗效外，DP在治疗高钙血症方面也非常有效，其骨源性几乎总是至关重要的。在恶性高钙血症中，人身上测试的三种DP，即依替膦酸二钠（EHDP）、氯屈膦酸二钠（C12 MDP）和阿仑膦酸钠（APD），静脉给药时在数天内可使血清钙水平下降。后两种制剂口服时也有效。DP在控制原发性甲状旁腺功能亢进引起的高钙血症方面也很有价值。目前正在进行研究以确定DP在预防恶性骨溶解中的作用，这与化疗的效果不同。
