Fiebig H, Behn I, Gruhn R, Typlt H, Kupper H, Ambrosius H
Allerg Immunol (Leipz). 1984;30(4):242-50.
A set of 6 monoclonal antibodies is characterized reacting only with human T-cells but not with B lymphocytes. The antibody BL-T1 binds to the E receptor, being there on all mature T cells and on the majority of thymocytes. All respectively the majority of peripheral T cells but only subpopulations of thymocytes are recognized by the monoclonals BL-T2, BL-T3, BL-T4 and BL-T5. For identification and quantification of mature human T cells especially the antibody BL-T2 is suitable. The antigen recognized by BL-E1 is missing on peripheral B lymphocytes but expressed not only on T cells but also on erythrocytes, monocytes and a fraction of granulocytes. The monoclonals discussed are compared with the monoclonals for identification of leucocyte differentiation antigens (cluster of differentiation) characterized on the 1st Int. Workshop on Human Leucocyte Differentiation Antigens (Paris, 1982).
一组6种单克隆抗体的特征是仅与人类T细胞发生反应，而不与B淋巴细胞发生反应。抗体BL-T1与E受体结合，所有成熟T细胞和大多数胸腺细胞上都有该受体。单克隆抗体BL-T2、BL-T3、BL-T4和BL-T5分别识别所有或大多数外周T细胞，但仅识别胸腺细胞的亚群。特别是抗体BL-T2适用于鉴定和定量成熟的人类T细胞。BL-E1识别的抗原在外周B淋巴细胞上缺失，但不仅在T细胞上表达，还在红细胞、单核细胞和一部分粒细胞上表达。将所讨论的单克隆抗体与用于鉴定白细胞分化抗原（分化簇）的单克隆抗体进行比较，这些抗原在第一届国际人类白细胞分化抗原研讨会上（巴黎，1982年）得到了表征。
