Horst M A, Robinson C P
Arch Int Pharmacodyn Ther. 1984 Dec;272(2):277-82.
The effects of selective histamine receptor stimulation on relaxation to norepinephrine (NE) were determined in four sizes of spirally cut porcine coronary arteries. The four sizes of porcine coronary artery were designated very large (greater than 4.0 mm o.d.), large (1.5-2.5 mm o.d.), medium (0.8-1.2 mm o.d.), and small (less than or equal to 0.5 mm o.d.). Histamine, dimaprit, 2-pyridylethylamine, and histamine plus either mepyramine or metiamide did not alter the concentration-response curve to NE. Thus histamine receptor stimulation does not change relaxations of porcine coronary arteries to NE.
在四种不同管径的螺旋状切割猪冠状动脉中，测定了选择性组胺受体刺激对去甲肾上腺素（NE）舒张作用的影响。四种管径的猪冠状动脉分别定义为极大型（外径大于4.0mm）、大型（外径1.5 - 2.5mm）、中型（外径0.8 - 1.2mm）和小型（外径小于或等于0.5mm）。组胺、二甲双胍、2 - 吡啶乙胺以及组胺与美吡拉敏或甲硫米特合用，均未改变对NE的浓度 - 反应曲线。因此，组胺受体刺激不会改变猪冠状动脉对NE的舒张作用。
