Robinson C, Christiansen V J, Horst M A
Artery. 1983;11(6):422-31.
Helically cut strips of rabbit mesenteric artery relax when exposed to histamine if their histamine H1 receptors are first blocked by 7 X 10(-6) M mepyramine. Relaxations are potentiated by 20 min pretreatment with 10(-6) M dibenamine. This dibenamine regimen also enhances relaxation of the strips to the selective H2 receptor agonist dimaprit, and to a lesser extent to papaverine which does not act on histamine receptors. This enhancement occurs both at 38 degrees and 22 degrees, and in mesenteric artery strips from rabbits reserpinized to deplete amine stores. Histamine has a greater relaxant effect on mesenteric artery strips at 22 degrees than at 38 degrees, normally. Dibenamine-treated strips do not relax more at the lower temperature, however. Thus, dibenamine nonselectively enhances relaxations of mesenteric artery and may enhance histamine-induced relaxations by an additional mechanism.
如果兔肠系膜动脉的组胺H1受体先用7×10⁻⁶ M美吡拉敏阻断，那么当暴露于组胺时，螺旋切割的兔肠系膜动脉条会松弛。用10⁻⁶ M二苄胺预处理20分钟可增强这种松弛作用。这种二苄胺处理方案还增强了动脉条对选择性H2受体激动剂地马普利的松弛反应，对不作用于组胺受体的罂粟碱的松弛反应增强程度较小。这种增强作用在38℃和22℃时均会出现，并且在经利血平处理以耗尽胺类储存的兔的肠系膜动脉条中也会出现。通常情况下，组胺在22℃时对肠系膜动脉条的舒张作用比在38℃时更强。然而，经二苄胺处理的动脉条在较低温度下并不会有更强的松弛反应。因此，二苄胺非选择性地增强肠系膜动脉的松弛作用，并且可能通过另一种机制增强组胺诱导的松弛作用。
