抗抑郁药对熟练技能表现的影响。

Effects of antidepressants on skilled performance.

作者信息

Linnoila M, Johnson J, Dubyoski K, Buchsbaum M S, Schneinin M, Kilts C

出版信息

Br J Clin Pharmacol. 1984;18 Suppl 1(Suppl 1):109S-120S. doi: 10.1111/j.1365-2125.1984.tb02589.x.

DOI:10.1111/j.1365-2125.1984.tb02589.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463331/

Abstract

Effects of amitriptyline 50 mg, desipramine 100 mg, and zimelidine 200 mg alone and in combination with ethanol 0.8 g/kg were investigated in healthy, male volunteers. Amitriptyline increased body sway and impaired tracking as well as information processing. It had an additive deleterious pharmacodynamic interaction with ethanol. Desipramine and zimelidine were free of adverse effects on performance and did not have significant interactions with ethanol. The dose of ethanol used in the present study did not inhibit biotransformation of the antidepressants.

摘要

在健康男性志愿者中研究了单独使用50毫克阿米替林、100毫克地昔帕明和200毫克齐美利定以及它们与0.8克/千克乙醇联合使用的效果。阿米替林增加了身体摇摆，损害了追踪能力以及信息处理能力。它与乙醇存在有害的药效学相加相互作用。地昔帕明和齐美利定对行为表现没有不良影响，且与乙醇没有显著相互作用。本研究中使用的乙醇剂量并未抑制抗抑郁药的生物转化。

相似文献

1

Effects of antidepressants on skilled performance.

Br J Clin Pharmacol. 1984;18 Suppl 1(Suppl 1):109S-120S. doi: 10.1111/j.1365-2125.1984.tb02589.x.

2

Effects of amitriptyline, desipramine and zimeldine, alone and in combination with ethanol, on information processing and memory in healthy volunteers.

Acta Psychiatr Scand Suppl. 1983;308:175-81. doi: 10.1111/j.1600-0447.1983.tb11121.x.

3

Effects of zimeldine, mianserin and amitriptyline on psychomotor skills and their interaction with ethanol a placebo controlled cross-over study.

Eur J Clin Pharmacol. 1984;27(2):181-9. doi: 10.1007/BF00544043.

4

Effects of amitriptyline and zimelidine in combination with ethanol.

Psychopharmacology (Berl). 1982;76(3):209-11. doi: 10.1007/BF00432546.

5

Effects of zimeldine and other antidepressants on skilled performance: a comprehensive review.

Acta Psychiatr Scand Suppl. 1983;308:135-40. doi: 10.1111/j.1600-0447.1983.tb11114.x.

6

Effects of chronic zimelidine and ethanol on psychomotor performance.

J Clin Psychopharmacol. 1985 Jun;5(3):148-53.

7

Acute effects of maprotiline, doxepin and zimeldine with alcohol in healthy volunteers.

Arch Int Pharmacodyn Ther. 1988 Jan-Feb;291:217-28.

8

Comparison of desipramine, amitriptyline, zimeldine and alaproclate in six animal models used to investigate antidepressant drugs.

Pharmacol Toxicol. 1988 Jan;62(1):42-50. doi: 10.1111/j.1600-0773.1988.tb01842.x.

9

Dose-dependent down-regulation of beta-adrenergic receptors after chronic intravenous infusion of antidepressants.

Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(5):673-82. doi: 10.1016/0278-5846(88)90011-5.

10

Acute kinetic and dynamic interactions of zimelidine with ethanol.

Clin Pharmacol Ther. 1984 Nov;36(5):654-60. doi: 10.1038/clpt.1984.236.

引用本文的文献

1

Pharmacokinetic and pharmacodynamic drug interactions with ethanol (alcohol).

Clin Pharmacokinet. 2014 Dec;53(12):1115-36. doi: 10.1007/s40262-014-0190-x.

2

The effects of fall-risk-increasing drugs on postural control: a literature review.

Drugs Aging. 2013 Nov;30(11):901-20. doi: 10.1007/s40266-013-0113-9.

3

Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects.

Br J Clin Pharmacol. 2005 May;59(5):495-510. doi: 10.1111/j.1365-2125.2005.02342.x.

4

Effects of adinazolam and diazepam, alone and in combination with ethanol, on psychomotor and cognitive performance and on autonomic nervous system reactivity in healthy volunteers.

Eur J Clin Pharmacol. 1990;38(4):371-7. doi: 10.1007/BF00315578.

5

Effects of single doses of alprazolam and diazepam, alone and in combination with ethanol, on psychomotor and cognitive performance and on autonomic nervous system reactivity in healthy volunteers.

Eur J Clin Pharmacol. 1990;39(1):21-8. doi: 10.1007/BF02657051.

本文引用的文献

1

Amitriptyline and ethanol: pharmacokinetic and pharmacodynamic interaction.

Eur J Clin Pharmacol. 1983;25(3):325-31. doi: 10.1007/BF01037943.

2

Drinking and driving in 753 general practice and psychiatric patients on psychotropic drugs.

Br J Psychiatry. 1969 Jan;115(518):99-100. doi: 10.1192/bjp.115.518.99.

3

Effects of alcohol on psychomotor performance of men and women.

J Stud Alcohol. 1978 May;39(5):745-58. doi: 10.15288/jsa.1978.39.745.

4

High-performance liquid chromatographic assay for imipramine, desipramine, and their 2-hydroxylated metabolites.

J Pharm Sci. 1979 Jun;68(6):703-5. doi: 10.1002/jps.2600680612.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。