Mocchetti I, Giorgi O, Schwartz J P, Costa E
Eur J Pharmacol. 1984 Nov 13;106(2):427-30. doi: 10.1016/0014-2999(84)90734-9.
The administration of drugs such as fenfluramine, p-chlorophenylalanine or 5,7-dihydroxytryptamine, which lower brain 5-hydroxytryptamine content, increases the enkephalin content of hypothalamus and striatum. None of these treatments changes proenkephalin mRNA content. On the basis of these results, we propose that 5-hydroxytryptamine does not increase the biosynthesis of enkephalin, but might increase the content of the neuropeptide by reducing peptide utilization.
服用诸如芬氟拉明、对氯苯丙氨酸或5,7-二羟基色胺等可降低脑5-羟色胺含量的药物，会增加下丘脑和纹状体中脑啡肽的含量。这些处理均未改变前脑啡肽mRNA的含量。基于这些结果，我们提出5-羟色胺不会增加脑啡肽的生物合成，但可能通过减少肽的利用来增加神经肽的含量。
