调节纹状体神经元活性的因素：原位杂交组织化学的新视角
Factors regulating the activity of striatal neurons: new perspectives from in situ hybridization histochemistry.
作者信息
Morris B
机构信息
MRC Molecular Neurobiology Unit, MRC Centre, Cambridge, UK.
出版信息
Cell Mol Neurobiol. 1990 Mar;10(1):51-8. doi: 10.1007/BF00733635.
Abstract
- The basal ganglia contain a variety of putative peptide neurotransmitters. In situ hybridization allows changes in the levels of the mRNAs encoding these neuropeptides to be assessed at the cellular level of resolution. 2. Alterations in the activity of pathways within the basal ganglia of the rat produce distinct effects on the different neuropeptide mRNAs. 3. The evidence, where available, suggests that mRNA levels provide an index of peptide turnover. 4. This approach has consequently revealed much new information on the regulation of neuronal activity in the basal ganglia.
摘要
- 基底神经节含有多种假定的肽类神经递质。原位杂交可在细胞分辨率水平评估编码这些神经肽的mRNA水平的变化。2. 大鼠基底神经节内通路活性的改变对不同的神经肽mRNA产生不同的影响。3. 现有证据表明，mRNA水平可作为肽类更新的指标。4. 因此，这种方法揭示了许多关于基底神经节神经元活动调节的新信息。
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