Moxon E R, Zwahlen A, Rubin L G, Hoiseth S, Connelly C
Infection. 1984;12 Suppl 1:S23-8. doi: 10.1007/BF01641736.
The successful development and implementation of rational strategies for the prevention of bacterial meningitis should be facilitated by acquiring a more detailed knowledge of its pathophysiology. We have used a biologically relevant rat model of meningitis in conjunction with classical microbial genetics and recombinant DNA technology to investigate the molecular basis of Haemophilus influenzae pathogenicity. These studies aim to define how specific bacterial genes mediate the potential of H. influenzae to colonize the nasopharynx, disseminate within the blood stream and invade the central nervous system. By identifying the state or stages in the pathogenic sequence for which the determinant is critical, this approach should also provide insight into the relevant host defense mechanisms which determine resistance or susceptibility. An understanding of the genetic basis of H. influenzae pathogenicity may develop basic knowledge relevant to the treatment and prevention of bacterial meningitis.
通过更详细地了解细菌性脑膜炎的病理生理学，应有助于成功制定和实施合理的预防策略。我们使用了一种与生物学相关的大鼠脑膜炎模型，结合经典微生物遗传学和重组DNA技术，来研究流感嗜血杆菌致病性的分子基础。这些研究旨在确定特定的细菌基因如何介导流感嗜血杆菌在鼻咽部定植、在血流中扩散以及侵入中枢神经系统的潜力。通过确定该决定因素在致病序列中至关重要的状态或阶段，这种方法还应能深入了解决定抵抗力或易感性的相关宿主防御机制。了解流感嗜血杆菌致病性的遗传基础可能会产生与细菌性脑膜炎治疗和预防相关的基础知识。
