Wieczorek Z, Zimecki M, Janusz M, Lisowski J, Starościk K
Arch Immunol Ther Exp (Warsz). 1984;32(5):537-41.
In the studies on mouse thymocyte subpopulations--non-glass-adherent (NAL) cortisone-sensitive (HCS), and glass-adherent (GAL) cortisone-resistant (HCR) thymocytes the existence of precursors for helper and suppressor cells of the autologous rosette formation was demonstrated. A proline-rich polypeptide (PRP), an immunoregulator induced differentiation of helper and suppressor cells from NAL and GAL cells, respectively. These cells elevate or inhibit formation of autologous rosette by thymocyte subpopulations in vitro. Helper activity was abolished by treatment with monoclonal anti-Lyt 1,1 antibodies and suppressor activity was totally inhibited after treatment with monoclonal anti-Lyt 2,1 antibodies.
在对小鼠胸腺细胞亚群的研究中——非玻璃黏附（NAL）的可的松敏感（HCS）细胞以及玻璃黏附（GAL）的可的松抵抗（HCR）胸腺细胞，证实了存在自身玫瑰花结形成的辅助细胞和抑制细胞的前体。一种富含脯氨酸的多肽（PRP），作为一种免疫调节剂，分别诱导NAL细胞和GAL细胞分化为辅助细胞和抑制细胞。这些细胞在体外可增强或抑制胸腺细胞亚群自身玫瑰花结的形成。用单克隆抗Lyt 1,1抗体处理可消除辅助活性，用单克隆抗Lyt 2,1抗体处理后抑制活性则完全被抑制。
