共轭性水平凝视性眼球震颤与血浆中游离苯妥英浓度：缺乏相关性。

Conjugate lateral gaze nystagmus and free phenytoin concentrations in plasma: lack of correlation.

作者信息

Riker W K, Downes H, Olsen G D, Smith B

出版信息

Epilepsia. 1978 Feb;19(1):93-8. doi: 10.1111/j.1528-1157.1978.tb05016.x.

DOI:10.1111/j.1528-1157.1978.tb05016.x

Abstract

Electrooculographic recordings during left and right conjugate lateral gaze fixation from 10 degrees to 50 degrees were made in 29 patients being treated with phenytoin. At the time of electrooculographic recordings, venous blood samples were drawn for analysis of total and free phenytoin plasma concentrations. Rhythmic horizontal nystagmus occurred in 7 patients, and only at extreme (40 degrees, 50 degrees) later gaze in 6 of these. Measurable free phenytoin levels in the 29 patients ranged from 0.2 to 3.2 mug/ml, and in the 7 patients with nystagmus were 0.6, 0.8, 1.0, 1.0, 1.7, 1.8, and 3.2 mug/ml. Neither the occurrence of nystagmus nor the degree of lateral gaze at onset could be correlated with free phenytoin concentrations in plasma.

摘要

对29名正在接受苯妥英治疗的患者进行了从10度到50度的左右共轭侧视注视期间的眼电图记录。在进行眼电图记录时，采集静脉血样以分析苯妥英的总血浆浓度和游离血浆浓度。7名患者出现了节律性水平眼球震颤，其中6名仅在极端（40度、50度）侧视时出现。29名患者中可测量的游离苯妥英水平在0.2至3.2微克/毫升之间，7名有眼球震颤的患者的水平分别为0.6、0.8、1.0、1.0、1.7、1.8和3.2微克/毫升。眼球震颤的发生或开始时的侧视程度均与血浆中游离苯妥英浓度无关。