苯妥英钠所致的舞蹈手足徐动症和脑病
Choreo-athetosis and encephalopathy induced by phenytoin.
作者信息
McLellan D L, Swash M
出版信息
Br Med J. 1974 Apr 27;2(5912):204-5. doi: 10.1136/bmj.2.5912.204.
Abstract
Two patients with intractable epilepsy who had been treated with various combinations of anticonvulsant drugs developed phenytoin encephalopathy. In both patients choreo-athetoid involuntary movements were prominent. Blood phenytoin concentrations were above 30 mug/ml. When phenytoin was given in smaller doses and its level in the blood fell the involuntary movements and other clinical manifestations disappeared.
摘要
两名患有顽固性癫痫的患者，曾接受多种抗惊厥药物联合治疗，出现了苯妥英脑病。两名患者均以舞蹈样手足徐动症样不自主运动最为突出。血液中苯妥英浓度高于30微克/毫升。当给予较小剂量的苯妥英且其血液水平下降时，不自主运动及其他临床表现消失。
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