Jarrett R J, Viberti G C, Argyropoulos A, Hill R D, Mahmud U, Murrells T J
Diabet Med. 1984 May;1(1):17-9. doi: 10.1111/j.1464-5491.1984.tb01915.x.
Forty-four non-insulin-dependent diabetics (NIDD), all with urine negative to Albustix, were studied in 1966/67. By the end of 1980, 17 had died, all but two from cardiovascular causes. All causes of mortality and time to death were significantly related in univariate analyses to age and to the overnight urinary albumin excretion rate (AER), but not to systolic and diastolic blood pressure levels or to duration of diabetes when the latter was corrected for age. Age and duration were highly correlated with each other. In multivariate analyses age and AER were independent predictors of both mortality and time to death, with AER having the greater degree of significance. Thus subclinically elevated albumin excretion rates ('microalbuminuria') indicate a substantially increased mortality risk in non-insulin-dependent diabetes.
1966年至1967年期间，对44名非胰岛素依赖型糖尿病患者（NIDD）进行了研究，这些患者的尿Albustix检测均为阴性。到1980年底，17人死亡，除两人外，均死于心血管疾病。在单变量分析中，所有死亡原因和死亡时间均与年龄以及夜间尿白蛋白排泄率（AER）显著相关，但与收缩压和舒张压水平或校正年龄后的糖尿病病程无关。年龄和病程之间高度相关。在多变量分析中，年龄和AER是死亡率和死亡时间的独立预测因素，AER的显著性更高。因此，亚临床白蛋白排泄率升高（“微量白蛋白尿”）表明非胰岛素依赖型糖尿病患者的死亡风险大幅增加。
