Rohner T J, Hannigan J
Invest Urol. 1980 Jan;17(4):324-7.
Norepinephrine, isoproterenol, and the phosphodiesterase inhibitor, theophylline, caused relaxation of in vitro dog detrusor strips associated with significant increases in detrusor cyclic AMP content. Bethanechol-induced detrusor contractions and alpha-adrenergic detrusor contractile responses to norepinephrine after propranolol were not associated with changes in cyclic AMP. Cyclic nucleotide metabolic pathways exist in detrusor muscle and offer another investigative approach to bladder dysfunction.
去甲肾上腺素、异丙肾上腺素和磷酸二酯酶抑制剂茶碱可使体外培养的犬逼尿肌条松弛，同时逼尿肌环磷酸腺苷（cAMP）含量显著增加。氨甲酰甲胆碱诱导的逼尿肌收缩以及普萘洛尔后去甲肾上腺素引起的α-肾上腺素能逼尿肌收缩反应与环磷酸腺苷的变化无关。环核苷酸代谢途径存在于逼尿肌中，为膀胱功能障碍提供了另一种研究方法。
