Blank K J, Murasko D M
Nature. 1980 Jan 31;283(5746):494-5. doi: 10.1038/283494a0.
A high percentage of AKR mice develop spontaneous leukaemia which has shown to be associated with the early expression of ecotropic murine leukaemia virus (MuLV) and the subsequent expression of xenotropic as well as polytropic MuLVs. Generally, mice infected with any one of several groups of viruses, including MuLVs, have been shown to produce interferon (IF). However, we report here that AKR mice produce no IF, despite that fact that infectious, endogenous MuLV is expressed in these mice from birth.
高比例的AKR小鼠会自发患上白血病，这种白血病已被证明与嗜亲性鼠白血病病毒（MuLV）的早期表达以及随后异嗜性和多嗜性MuLV的表达有关。一般来说，感染包括MuLV在内的几类病毒中任何一种的小鼠，都已被证明会产生干扰素（IF）。然而，我们在此报告，尽管从出生起这些小鼠中就表达了具有传染性的内源性MuLV，但AKR小鼠却不产生IF。
