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小鼠嗜异性C型病毒感染对犬类细胞化学诱导体外致癌作用的抑制

Inhibition of chemically induced carcinogenesis of canine cells in vitro by infection with mouse xenotropic type C virus.

作者信息

Rhim J S, Arnstein P

出版信息

J Natl Cancer Inst. 1980 Feb;64(2):345-51. doi: 10.1093/jnci/64.2.345.

DOI:10.1093/jnci/64.2.345
PMID:6243716
Abstract

C57L mouse xenotropic type C virus infection inhibited N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced in vitro transformation of embryo cells from inbred beagles. Treatment with MNNG induced in vitro neoplastic transformation in uninfected canine cells but not in C57L virus-infected canine cells; the C57L virus-infected canine cells not treated with MNNG also remained untransformed. In this dog cell system, preinfection with a C57L mouse xenotropic type C virus inhibited in vitro neoplastic transformation induced by MNNG.

摘要

C57L小鼠嗜异性C型病毒感染抑制了N-甲基-N'-硝基-N-亚硝基胍（MNNG）诱导的近交系比格犬胚胎细胞的体外转化。用MNNG处理可诱导未感染犬细胞发生体外肿瘤转化，但不能诱导C57L病毒感染的犬细胞发生转化；未用MNNG处理的C57L病毒感染的犬细胞也未发生转化。在这个犬细胞系统中，预先感染C57L小鼠嗜异性C型病毒可抑制MNNG诱导的体外肿瘤转化。

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