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通过对先天性传播的鼠白血病病毒进行被动免疫来预防野生小鼠的麻痹和抑制淋巴瘤。

Prevention of paralysis and suppression of lymphoma in wild mice by passive immunization to congenitally transmitted murine leukemia virus.

作者信息

Gardner M B, Estes J D, Casagrande J, Rasheed S

出版信息

J Natl Cancer Inst. 1980 Feb;64(2):359-64. doi: 10.1093/jnci/64.2.359.

DOI:10.1093/jnci/64.2.359
PMID:6243718
Abstract

Lake Casitas wild mice were passively immunized as newborns with antiserum to congenitally transmitted murine leukemia virus. Immunization with immunoglobulin having a high neutralizing titer to ecotropic virus and a low titer to amphotropic virus correlated with the complete prevention of paralysis and a slight (25%), but statistically insignificant, reduction in the incidence of lymphoma. Occurrence of other tumor types and total mortality rate were not affected by immunization.

摘要

卡西塔斯湖野生小鼠在新生时用针对先天性传播的鼠白血病病毒的抗血清进行了被动免疫。用对嗜亲性病毒具有高中和效价而对兼嗜性病毒具有低效价的免疫球蛋白进行免疫,与完全预防麻痹以及淋巴瘤发病率轻微降低(25%,但无统计学意义)相关。免疫对其他肿瘤类型的发生和总死亡率没有影响。

相似文献

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Prevention of paralysis and suppression of lymphoma in wild mice by passive immunization to congenitally transmitted murine leukemia virus.通过对先天性传播的鼠白血病病毒进行被动免疫来预防野生小鼠的麻痹和抑制淋巴瘤。
J Natl Cancer Inst. 1980 Feb;64(2):359-64. doi: 10.1093/jnci/64.2.359.
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Congenital transmission of murine leukemia virus from wild mice prone to the development of lymphoma and paralysis.
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A notable phenomenon recapitulated. A fusion product of a murine lymphoma cell and a leukemia virus-neutralizing antibody-producer host plasma cell formed spontaneously and secreting the specific antibody continuously.一个值得注意的现象重现了。一种小鼠淋巴瘤细胞与一种白血病病毒中和抗体产生宿主浆细胞的融合产物自发形成并持续分泌特异性抗体。
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引用本文的文献

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Genetic control of retroviral disease in aging wild mice.衰老野生小鼠逆转录病毒疾病的遗传控制
Genetica. 1993;91(1-3):199-209. doi: 10.1007/BF01435998.
2
Molecular cloning of infectious viral DNA from ecotropic neurotropic wild mouse retrovirus.从亲嗜性嗜神经性野生小鼠逆转录病毒中克隆感染性病毒DNA
J Virol. 1983 Mar;45(3):1159-63. doi: 10.1128/JVI.45.3.1159-1163.1983.
3
Role of immunity in age-related resistance to paralysis after murine leukemia virus infection.免疫在小鼠白血病病毒感染后与年龄相关的麻痹抗性中的作用。
J Virol. 1984 Dec;52(3):734-8. doi: 10.1128/JVI.52.3.734-738.1984.