Collier H O
Nature. 1980 Feb 14;283(5748):625-9. doi: 10.1038/283625a0.
Experiments on whole animals, guinea pig isolated ileum, individual neurones in situ and cultured neuroblastoma--glioma hybrid cells indicate that opiate dependence and associated tolerance develop within neurones bearing specific opiate receptors (opiate-sensitive neurones). The essential change appears to be an hypertrophy of the cyclic AMP system, in response to inhibition by opiate of a neuronal adenylate cyclase.
对整体动物、豚鼠离体回肠、原位单个神经元以及培养的神经母细胞瘤 - 胶质瘤杂交细胞进行的实验表明，阿片类药物依赖性及相关耐受性在具有特定阿片受体的神经元（阿片敏感神经元）内形成。本质性变化似乎是环磷酸腺苷（cAMP）系统的肥大，这是对阿片类药物抑制神经元腺苷酸环化酶的一种反应。
